Melanotan 1 peptide therapy.

In recent years, the quest for a perfect tan has become increasingly popular among individuals seeking a sun-kissed complexion. While traditional methods such as sunbathing and tanning beds pose risks to skin health, advancements in the field of peptide research have led to the development of Melanotan 1 (MT-1). A synthetic peptide, MT-1 stimulates the production of melanin in the body. It offers a safer alternative for achieving a desirable tan. In this article, we delve into the origins, functions, benefits, and potential side effects of Melanotan 1.

Annamarie Salyer FNP-C is a peptide therapy specialist at bionwoRx. She offers many types of peptide therapy treatments. Annamarie will discuss your desired results and help  determine the peptide therapy treatment that is right for you.

Origins and Mechanism of Action

Melanotan 1, also known as Afamelanotide, was initially developed at the University of Arizona in the late 1980s. The research aimed to understand the effects of melanocyte-stimulating hormone (MSH) on the body’s pigmentation process. Scientists discovered that a shorter chain of amino acids, known as a peptide, was responsible for triggering the production of melanin in the skin. This breakthrough led to the creation of Melanotan 1, a synthetic analog of the naturally occurring MSH.

Melanotan 1 works by binding to the melanocortin-1 receptor (MC1R) in the skin cells. This receptor is responsible for regulating the production of eumelanin. This pigment gives color to the skin, hair, and eyes. By activating MC1R, Melanotan 1 stimulates the synthesis and release of eumelanin, which results in increased pigmentation and a darker skin tone.

Benefits and Uses

1. Sunless Tanning: Melanotan 1 offers a sunless tanning solution that reduces the need for harmful ultraviolet (UV) exposure. By promoting the production of melanin, it enables individuals to achieve a natural-looking tan without subjecting their skin to the damaging effects of the sun’s UV rays. This is particularly beneficial for people with fair skin who are more prone to sunburns and skin damage.

2. Photoprotection: Melanotan 1 has shown potential as a photoprotective agent. By increasing melanin levels, it provides a natural defense mechanism against UV radiation. Eumelanin absorbs UV rays, which reduces their penetration into the skin and minimizes the risk of sunburns and DNA damage. This effect may prove beneficial in preventing certain types of skin cancer.

3. Erectile Dysfunction: Melanotan 1 has been investigated for its potential in treating erectile dysfunction (ED). Studies suggest that the peptide may enhance sexual function. It increases nitric oxide production in the body, leading to improved blood flow to the genital region. However, further research is needed to establish its efficacy and safety in this regard.

Side Effects and Precautions

While Melanotan 1 offers promising benefits, it is crucial to consider potential side effects and precautions associated with its use. Some of the reported side effects include:

1. Nausea and Facial Flushing: Melanotan 1 may cause temporary side effects. This includes mild nausea and facial flushing, which tends to subside over time as the body adjusts to the peptide.

2. Increased Libido: Some users report an increase in sexual desire and arousal as a side effect of Melanotan 1. While this may be seen as a positive outcome for individuals experiencing sexual difficulties, it is important to note that the effects may vary from person to person.

3. Freckles and Darkening of Moles: Melanotan 1 can lead to the darkening of existing moles and the development of new freckles. This may be a concern for individuals with a history of skin conditions or those at risk of developing melanoma. Regular monitoring of the skin and consultation with a dermatologist are recommended.

4. Unknown Long-term Effects: Since Melanotan 1 is a relatively recent development, its long-term effects and safety profile are not yet fully understood. Further research is required to assess any potential risks associated with prolonged use.

It is essential to use Melanotan 1 responsibly and under the guidance of an experienced peptide therapy specialist. The peptide is not approved by regulatory agencies such as the Food and Drug Administration (FDA) for cosmetic purposes, and its use is often considered off-label.

Administation and Dosage

Melanotan 1 is typically administered via subcutaneous injection. A small needle is used to deliver the peptide directly into the fatty tissue beneath the skin. The dosage varies depending on factors such as individual response, desired level of pigmentation, and the frequency of use. It is crucial to follow the recommended dosage instructions provided by your provider.


Melanotan 1 has emerged as a groundbreaking peptide in the pursuit of a safe and effective tan. It stimulates the production of melanin and offers an alternative to traditional tanning methods that carry risks to skin health. Its benefits include sunless tanning, photoprotection, and potential applications in treating erectile dysfunction. However, it is essential to be aware of potential side effects and exercise caution when using Melanotan 1. Consulting with a healthcare professional and practicing responsible usage are vital to minimize risks and ensure optimal results. As further research continues, the full potential and long-term effects of Melanotan 1 will be better understood, providing valuable insights into its efficacy and safety.

Schedule a consultation today

Do you want to find out more about Melanotan 1? If so, we encourage you to schedule a consultation with Annamarie Salyer FNP-C at bionwoRx.


This peptide is no longer available due to the FDA ruling on Category 2 of the Bulk Substances Nominated Under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act.

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BionwoRx  offers comprehensive, individualized, and a holistic approach to total wellness and age management. By focusing on customized medicine, BionwoRx helps patients earlier in the aging process in order to help prevent, rather than treat age-related issues. Founded and run by Annamarie Salyer FNP-C, BionwoRx is dedicated to helping patients identify the root causes of any issues in order to restore the body to its peak performance, alleviate symptoms and ultimately, reverse the effects of aging and prevent age-related diseases. BionwoRx creates personalized treatment plans with proven, effective and safe anti-aging solutions that include highly advanced testing, bioidentical hormone therapy, nutrient therapy, sexual health programs, medical aesthetics, weight loss and much more.

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At Bion Aesthetics and Med Spa, we focus on finding a comprehensive, individualized, and scientific approach to aesthetic and medical rejuvenation.

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