MOTS-c peptide therapy

MOTS-c is a relatively new peptide of 16 amino acids that promote metabolic balance. It regulates metabolic functions throughout the body. For instance, it turns glucose into usable energy.

The DNA in the cell nucleus encodes most peptides. But, the mitochondria’s DNA encodes MOTS-c making it unique among peptides.

Research by the University of Southern California found this peptide may help fight weight gain and normalize metabolism – similar to effects mostly linked with exercise.

In mouse studies, the peptide aided glucose metabolism, even when the mice ate a high-fat diet.

These initial studies could indicate improved blood sugar control for those with obesity and type 2 diabetes.

Annamarie Salyer FNP-C is a peptide therapy specialist at Bion Aesthetics and Med Spa in Indianapolis, IN offering MOTS-c for patients near Greenwood, IN, Carmel, IN, and Fishers, IN. She offers a wide variety of cutting edge peptide therapy treatments. She can help you find the right treatment for your unique needs.


Humans evolved to have flexible metabolism. Meaning we can adapt according to energy supply and demand.

Our bodies store the optimal amounts of amino acids, fatty acids, and glucose to use during food shortages or times with higher energy demand. But, eating excess calories and processed food regularly and inactivity causes metabolic inflexibility and dysfunction.

Dysfunctional metabolism may cause weight gain in various ways because they:

  • Stops muscles from using fats instead of carbohydrates for energy demands.
  • Impairs the body’s ability to manage food intake and energy use.
  • Distorts the body’s ability to recognize nutrients and respond suitably, as is the case with insulin resistance.

Besides optimal mitochondria function, our bodies need proper energy intake and use, as well as glucose and insulin control, to stay healthy.

And, because mitochondria control metabolism on a cellular level, fixing the mitochondria may improve the metabolism.

Metabolic diseases

We associate aging with a decline of mitochondrial function and developing age-related diseases, such as diabetes and metabolic syndrome. And since MOTS-c levels fall with age, declining mitochondrial-derived peptides (MDP) may relate to metabolic decline.

Thus, regular MDP treatments may improve the abnormal metabolism linked with aging in humans.

How MOTS-c might help

MOTS-c has a long list of possible benefits. Most notably, it may improve physical function, insulin sensitivity, age-related metabolic diseases, and obesity.

One of the signs of aging is the gradual loss of cell function. In turn, this inhibits the working tissue of organs and leads to less physical ability. As a result, aging is the leading risk for chronic disease.

We link aging with reduced MOTS-c levels in many tissues, including skeletal muscle and circulation.

According to study results, MOTS-c treatment helped middle-aged and old mice run significantly longer and further than untreated mice. What’s more, old mice outperformed untreated middle-aged mice. The results suggest physical re-programming rather than just rejuvenation.

In other words, MOTS-c seems to increase exercise ability on a cellular level.

MOTS-c benefits

  • Promotes fatty acid metabolism in the liver
  • Promotes metabolic flexibility and homeostasis
  • Helps regulate mitochondrial energy
  • Protects against age and diet dependent insulin resistance and obesity
  • Helps with weight loss
  • Promotes resistance to metabolic stress
  • Improves exercise capacity
  • Helps prevent osteoporosis
  • Improves glucose regulation
  • Promotes cell differentiation to form osteoblasts

Helps with diet induced obesity

The peptide may affect obesity, as well.

The peptide helps activate AMPK in mice on a high-fat diet. For this reason, it may prevent diet-induced obesity.

The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Cells activate AMPK when they are running low on energy. It’s also activated throughout the body after exercise or during calorie restriction. Studies show that compounds that activate AMPK may promote health. For instance, it may reverse diabetes, enhance heart health, treat mitochondrial diseases, and even increase life span.

The mice also used oxygen and glucose more efficiently and generated more heat. As a result, they burned more energy.

The study suggests that MOTS-c may prevent diet-induced obesity because it increases energy use and heat production and improves insulin sensitivity and glucose use.

While the peptide didn’t seem to affect body weight with regular diets, it can support weight loss in some cases.

Schedule a consultation today for MOTS-c in Indianapolis, IN

Do you live near Greenwood, IN, Carmel, IN or Fishers, IN, and want to find out more about MOTS-c If so, we encourage you to schedule a consultation with Annamarie Salyer FNP-C at Bion Aesthetics and Med Spa in Indianapolis, IN to determine if MOTS-c is right for you.

Share This Story, Choose Your Platform!

Bion Aesthetics and Med Spa offers comprehensive, individualized, and a holistic approach to total wellness and age management. By focusing on customized medicine, Bion Aesthetics and Med Spa helps patients earlier in the aging process in order to help prevent, rather than treat age-related issues. Founded and run by Annamarie Salyer FNP-C, Bion Aesthetics and Med Spa is dedicated to helping patients identify the root causes of any issues in order to restore the body to its peak performance, alleviate symptoms and ultimately, reverse the effects of aging and prevent age-related diseases. Bion Aesthetics and Med Spa creates personalized treatment plans with proven, effective and safe anti-aging solutions that include highly advanced testing, bioidentical hormone therapy, nutrient therapy, sexual health programs, medical aesthetics, weight loss and much more.

Blog Categories

Request a consultation

Get started today.

DO NOT send personal health information through this form.

Bion Aesthetics and Med Spa

Who we are

At Bion Aesthetics and Med Spa, we focus on finding a comprehensive, individualized, and scientific approach to aesthetic and medical rejuvenation.

Recent posts